β-Catenin (clone 4F2), anti-human, mouse, rat

Background:
The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.

Synonyms: armadillo, CTNNB, MRD19

Cellular Location: Cell junction Cell membrane Cytoplasm Nucleus adherens junction centrosome cytoskeleton microtubule organizing center spindle pole

Immunogen:
Recombinant Protein

Gene Symbol: β-Catenin

Gene ID: 1499

Swiss prot: P35222

Calculated MW: 92kDa

Recommended dilution:
WB 1:1000-2000, IHC 1:200-500,

Purity:
Saturated ammonium sulfate precipitation

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.