B Raf (clone 4E1-E1-F9), anti-human, mouse

Background:
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Synonyms: B-raf, B-RAF1, BRAF1, NS7, RAFB1, B-RAF1, BRAF1, NS7, RAFB1

Cellular Location: Cell membrane Cytoplasm Nucleus

Immunogen:
Purified recombinant human B Raf protein fragments expressed in E.coli.

Gene Symbol: B Raf

Gene ID: 673

Swiss prot: P15056

Calculated MW: 87kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.