B7-H3/CD276 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Immunology, Stem Cells

Synonyms:
CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2

Immunogen: A synthetic peptide of human B7-H3/CD276 (NP_001019907.1).

Swissprot: Q5ZPR3
Gene ID: 80381

Calculated MW: 33 kDa/52 kDa/57 kDa
Observed MW: 115 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.