B7-H4 polyclonal, anti-human, mouse, rat

Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens

Pathway and Disease: Cancers, Immune System, Signaling Molecules and Interaction

Description:
Immune costimulatory protein B7-H4 (B7-H4) is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell response. By arresting cell cycle, B7-H4 inhibits growth, cytokine secretion and cytotoxicity development. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7-H4 is also involved in promoting epithelial cell transformation. B7-H4 can be a predictive marker for renal cell carcinoma.

Alternate Names: V-set domain-containing T-cell activation inhibitor 1, Immune costimulatory protein B7-H4, B7h.5, T-cell costimulatory molecule B7x, Protein B7S1, VTCN1, B7H4

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-500

Accession No.: Q7Z7D3

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human B7-H4.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Zhao X et al. 2016. Oncol Rep. 36(1): 419-27. PMID 27177355.
[2] Galazka K et al. 2012. American Journal of Reproductive Immunology. 68(1):85-93. PMID 22530960.
[3]Basta P et al. American Journal of Reproductive Immunology. 65(2):164-172. PMID 20645939.
[4] Arigami T et al. 2011. Medicine. World Journal of Surgery. 35(9):2051-2057. PMID 21748517.
[5] Jung S et al. Korean Journal of Urology. 2011. 52(2): 90-95. PMID 21379424.