BACE(CT) polyclonal, anti-human, mouse antibody
€355.00
In stock
SKU
AC-ABV10798-100
Catalog Number: AC-ABV10798-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
Request Information
Background:
Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-so µght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Other Names:
BACE (CT). Asp2
Primary Accession: P56817
Gene Name: BACE1 (HGNC:933)
Gene ID: 23621
Concentration (mg/ml): 1 mg/ml
Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-so µght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Other Names:
BACE (CT). Asp2
Primary Accession: P56817
Gene Name: BACE1 (HGNC:933)
Gene ID: 23621
Concentration (mg/ml): 1 mg/ml
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