BAG2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Description:
Rabbit IgG polyclonal antibody for BAG family molecular chaperone regulator 2 (BAG2) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
BAG 2 antibody, BAG family molecular chaperone regulator 2 antibody, BAG-2 antibody, BAG-family molecular chaperone regulator-2 antibody, Bag2 antibody, BAG2_HUMAN antibody, BCL 2 associated athanogene 2 antibody, Bcl-2-associated athanogene 2 antibody, BCL2 associated athanogene 2 antibody, BCL2-associated athanogene 2 antibody, dJ417I1.2(BAG family molecular chaperone regulator 2) antibody, dJ417I1.2 antibody, KIAA0576 antibody, MGC149462 antibody, OTTHUMP00000016668 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human BAG2(1-14aa MAQAKINAKANEGR), different from the related mouse and rat sequences by two amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human BAG2(1-14aa MAQAKINAKANEGR), different from the related mouse and rat sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.