BAG2 Polyclonal Antibody

Background:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Research Area: Cell Biology,Signal Transduction,Cancer,Metabolism

Synonyms:
BAG 2, BAG family molecular chaperone regulator 2, BAG-2, BAG-family molecular chaperone regulator-2, Bag2, BAG2, BCL 2 associated athanogene 2, Bcl-2-associated athanogene 2, BCL2 associated athanogene 2, BCL2-associated athanogene 2, dJ417I1.2 (BAG family molecular chaperone regulator 2), dJ417I1.2, KIAA0576, MGC149462, OTTHUMP00000016668

Immunogen: Synthetic peptide of human BAG2

Swissprot: O95816
Gene Accession: NP004273

Calculated MW: 24 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.