Bag3 polyclonal, anti-human

Background:
The Bag family of proteins are characterized by the presence of a 45 amino acid Bag domain through which they bind with high affinity to the ATPase domain of HSP 70, thereby negatively regulating HSP 70 chaperone activity. Bag-3 (Bcl-2-associated athanogene 3), also known as BIS or CAIR-1, is a 575 amino acid protein that contains one C-terminal Bag domain and two N-terminal WW domains. Like other members of the Bag family, Bag-3 functions to inhibit the chaperone activity of HSP 70, specifically by promoting the release of HSP 70-bound substrates. Additionally, Bag-3 exhibits anti-apoptotic activity via cell cycle control, suggesting a possible role for Bag-3 in tumor progression. The gene encoding Bag-3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

Alternative Name:
BAG-3, BAG3, BIS, BAG 3, BAG family molecular chaperone regulator 3, BAG-3, Bag3, BAG3, Bcl 2 binding protein, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, BCL2 associated athanogene 3, BCL2 binding athanogene 3, BIS, CAIR 1, Docking protein CAIR 1, Docking protein CAIR-1, MFM6,

Application Dilution:
WB:1:1,000-1:2,000
IHC:1:50-1:200

Specificity: Bag3 polyclonal antibody detects endogenous levels of Bag3 protein.

Immunogen:
recombinant protein

MW: 75 kDa

Swiss-Prot: O95817(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.