BAG3 polyclonal, anti-human, mouse

Background:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Synonyms: BIS, MFM6, BAG-3, CAIR-1

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human BAG3

Gene Symbol: BAG3

Gene ID: 9531

Swiss prot: O95817

Calculated MW: 62kDa

Recommended dilution:
WB 1:500-2000, IHC 1:40-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.