Bag3 polyclonal, anti-human, rat

Quantity: 100 µg

Background:
BAG family molecular chaperone regulator 3(BAG3) is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones. BAG3 mutations are responsible for familial dilated cardiomyopathy. BAG3 polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus. In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity in flies, mice and men.

Description:
Rabbit IgG polyclonal antibody for BAG family molecular chaperone regulator 3 (BAG3) detection. Tested with WB, IHC-P in Human, Rat.

Synonyms:
BAG 3 antibody, BAG family molecular chaperone regulator 3 antibody, BAG-3 antibody, Bag3 antibody, BAG3_HUMAN antibody, Bcl 2 binding protein antibody, Bcl-2-associated athanogene 3 antibody, Bcl-2-binding protein Bis antibody, BCL2 associated athanogene 3 antibody, BCL2 binding athanogene 3 antibody, BIS antibody, Docking protein CAIR 1 antibody, Docking protein CAIR-1 antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Bag3 recombinant protein (Position: H100-N561). Human Bag3 shares 84.1% amino acid (aa) sequence identity with mouse Bag3.E.coli-derived human Bag3 recombinant protein (Position: H100-N561). Human Bag3 shares 84.1% amino acid (aa) sequence identity with mouse Bag3.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.