BAG5 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7862
Background:
Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.
Alternative Name:
BAG family molecular chaperone regulator 5, BAG-5, BAG5, BAG5_HUMAN, Bcl-2-associated athanogene 5, BCL2 associated athanogene 5, KIAA0873,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.
Immunogen:
Recombinant full length Human BAG5.
MW: ~ 51 kDa
Swis Prot.: Q9UL15
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.
Alternative Name:
BAG family molecular chaperone regulator 5, BAG-5, BAG5, BAG5_HUMAN, Bcl-2-associated athanogene 5, BCL2 associated athanogene 5, KIAA0873,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.
Immunogen:
Recombinant full length Human BAG5.
MW: ~ 51 kDa
Swis Prot.: Q9UL15
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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