BAIAP2L1 Polyclonal Antibody

Background:
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.

Research Area: Signal Transduction

Synonyms:
BAI1 associated protein 2 like 1, BAI1 associated protein 2 like protein 1, BAI1-associated protein 2-like protein 1, Baiap2l1, BI2L1, Brain specific angiogenesis inhibitor 1 associated protein 2 like protein 1, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, FLJ42275, Insulin receptor tyrosine kinase substrate, IRTKS

Immunogen: Fusion protein of human BAIAP2L1

Swissprot: Q9UHR4
Gene Accession: BC013888

Calculated MW: 57 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.7 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.