BAK polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BAK, officially called Bcl2 antagonist killer, is a protein that in humans, encoded by the BAK gene. The BAK protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. BAK gene spans 7.6 kb and contains 6 exons. By Southern blot analysis of genomic DNA from human/rodent somatic cell hybrids, BAK gene is localized to chromosome 6. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Description:
Rabbit IgG polyclonal antibody for Bcl-2 homologous antagonist/killer (BAK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Apoptosis Regulator Bak antibody, BAK antibody, BAK like antibody, Bak NT antibody, BAK_HUMAN antibody, BAK1 antibody, Bcl 2 homologous antagonist/killer antibody, Bcl 2 like 7 protein antibody, Bcl-2 homologous antagonist/killer antibody, Bcl-2-like protein 7 antibody, BCL2 antagonist/killer 1 antibody, Bcl2 like 7 Protein antibody, Bcl2-L-7 antibody, BCL2L7 antibody, CDN1 antibody, Cell death inhibitor 1 antibody, MGC117255 antibody, MGC3887 antibody, NBak antibody, Pro apoptotic protein BAK antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human BAK recombinant protein (Position: A22-S211). Human BAK shares 78.3 % amino acid (aa) sequence identity with mouse BAK.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.