BAP1 polyclonal, anti-human, mouse, rat

Background:
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

Synonyms: UCHL2, hucep-6, HUCEP-13

Cellular Location: Nucleus Cytoplasm

Immunogen:
Recombinant protein of human BAP1

Gene Symbol: BAP1

Gene ID: 8314

Swiss prot: Q92560

Calculated MW: 80 kDa

Recommended dilution:
WB 1:200-1000, IHC 1:40-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.