BAP1 Polyclonal Antibody

Background:
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
BAP 1, Bap1, BAP1, BRCA 1 associated protein 1, BRCA1 associated protein 1, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1, Cerebral protein 13, Cerebral protein 6, DKFZp686N04275, FLJ35406, FLJ37180, HUCEP 13, Hucep 6, HUCEP13, Hucep6, KIAA0272, TPDS, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl terminal hydrolase BAP 1, Ubiquitin carboxyl terminal hydrolase BAP1, Ubiquitin carboxyl-terminal hydrolase BAP1, UCHL2

Immunogen: Fusion protein of human BAP1

Swissprot: Q92560
Gene Accession: BC001596

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.8 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.