BAP31 polyclonal, anti-human, mouse

Background:
BAP31, a human Bcl-2-interacting protein, is an integral membrane protein that is a component of a protein complex in the endoplasmic reticulum. This protein complex mechanically bridges an apoptosis-initiating caspase, like procaspase-8, with the anti-apoptotic regulator Bcl-2 or Bcl-XL. The cytosolic domain of BAP31 contains two identical caspase recognition sites, which are preferentially cleaved by initiator caspases, including caspase 8. Cleavage of BAP31 during apoptosis generates a p20 fragment, which remains integrated in the membrane and, when expressed ectopically, is a potent inducer of cell death. BAP31 cleavage is important for manifesting cytoplasmic apoptotic events associated with membrane fragmentation and in the cross talk between mitochondria and the endoplasmic reticulum during Fas- mediated apoptosis. The BAP31 gene is ubiquitously expressed in murine tissues and is located on the X chromosome in both mouse and human.

Alternative Name:
BCR-associated protein 31, Bap31, BCAP31, BAP31, DXS1357E, 6C6 AG, 6C6 AG tumor associated antigen, 6C6-AG tumor-associated antigen, 6C6AG, 6C6AG tumor associated antigen, Accessory protein BAP 31, Accessory protein BAP31, B cell receptor associated protein 31, B-cell receptor-associated protein 31, BA31, BAP 31, Bap31, BAP31, BCAP 31, BCAP31, BCR associated protein Bap 31, BCR associated protein Bap31, BCR-associated protein 31, CDM, CDM protein, DXS1357E, MS950, p28, p28 Bap31, Protein CDM, RP23-329M9.5,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: BAP31 polyclonal antibody detects endogenous levels of BAP31 protein.

Immunogen:
Synthetic peptide within the C-terminus of human BAP31.

MW: 28 kDa

Swiss-Prot: P51572(Human) Q61335(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.