BARD1 antibody (clone 2A11), anti-human
€435.00
In stock
SKU
AC-AT1268a
Catalog Number: AC-AT1268a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: IF, E
Request Information AC-AT1268a">Request Information
Background:
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Other Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Antigen Type:
Recombinant Protein
Gene Name: BARD1
Gene ID: 580
NCBI Accession: NP_000456.2
Primary Accession: Q99728
Other Accession: NM_000465
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Other Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Antigen Type:
Recombinant Protein
Gene Name: BARD1
Gene ID: 580
NCBI Accession: NP_000456.2
Primary Accession: Q99728
Other Accession: NM_000465
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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