BARD1 polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP10664a
Catalog Number: AC-AP10664a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19063
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19063
Applications: WB
Datasheet
Request Information
Background:
BARD1 is a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Other Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Target/Specificity:
This BARD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1.
Antigen Region:
101-131
Antigen Type: Synthetic Peptide
Gene Name: BARD1
Gene ID: 580
Primary Accession: Q99728
NCBI Accession: NP_000456.2
Other Accession: NP_000456
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
BARD1 is a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Other Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Target/Specificity:
This BARD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1.
Antigen Region:
101-131
Antigen Type: Synthetic Peptide
Gene Name: BARD1
Gene ID: 580
Primary Accession: Q99728
NCBI Accession: NP_000456.2
Other Accession: NP_000456
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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