Bax (clone 2B12) mouse monoclonal, anti-human, monkey

Backgroud: Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.

Synonyms: Apoptosis regulator BAX, BAX, Bcl-2-like protein 4, BCL2-associated X protein, Bcl2-L-4, BCL2L4

Gene Name: BAX

Gene ID: 581

SwissProt ID: Q07812

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.