BAX polyclonal, anti-human

Background:
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7

Synonyms: Bcl2-L-4, Bax-protein, BAX_HUMAN, BAXA

Cellular Location: Cytoplasm Cell membrane

Immunogen:
A synthetic peptide of human BAX

Gene Symbol: BAX

Gene ID: 581

Swiss prot: Q07812

Calculated MW: 21kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.