Bax polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BAX(Bcl-2 Associated X Protein) is a member of the Bcl-2 gene family, it encodes a 21-kDa protein whose association with Bcl-2 is believed to play a critical role in regulating apoptosis. Human BAX gene is located in the q13.3-q13.4 region of human chromosome 19. Bax is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. It resides in an inactive state in the cytosol of many cells. Bax consists of 9 alpha helices and has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. Bax is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane(alpha) and two forms of cytosolic protein(beta and gamma). BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. They are critical mediators of B cell death induced by multiple stimuli.

Description:
Rabbit IgG polyclonal antibody for Apoptosis regulator BAX (BAX) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
apoptosis regulator BAX antibody, Apoptosis regulator BAX cytoplasmic isoform beta antibody, Apoptosis regulator BAX membrane isoform alpha antibody, BAX antibody, Bax isoform psi antibody, BAX protein cytoplasmic isoform delta antibody, Bax protein cytoplasmic isoform delta. antibody, Bax protein cytoplasmic isoform gamma antibody, Bax zeta antibody, Bax-protein antibody, BAX_HUMAN antibody, Bcl-2-like protein 4 antibody, BCL2 associated X protein antibody, BCL2 associated X protein omega antibody, BCL2 associated X protein transcript variant delta2 antibody, Bcl2-L-4 antibody, BCL2L4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Bax(19-33aa IMKTGALLLQGFIQD), different from the related mouse and rat sequences by one amino acid.A synthetic peptide corresponding to a sequence at the N-terminus of human Bax(19-33aa IMKTGALLLQGFIQD), different from the related mouse and rat sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.