BAX polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Synonyms: BCL2L4

Cellular Location: Cytoplasm Cytoplasm Mitochondrion membrane Single-pass membrane protein

Immunogen:
A synthetic peptide of human BAX

Gene Symbol: BAX

Gene ID: 581

Swiss prot: Q07812

Calculated MW: 21kDa

Recommended dilution:
WB 1:500-2000, IHC 1:100-200, IF 1:50-200, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.