BAX Polyclonal Antibody
€0.00
In stock
SKU
E-AB-10049
Catalog Number: E-AB-10049
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,ELISA
Datasheet, Questions? Contact us!
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,ELISA
Datasheet, Questions? Contact us!
Background:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Research Area: Cancer, Cell Biology, Metabolism
Synonyms:
Apoptosis regulator BAX, BAX, Bax-protein, BAX, BAXA, Baxdelta2G9, Baxdelta2G9omega, Baxdelta2omega, Bcl-2-like protein 4, BCL2 associated X protein, BCL2 associated X protein omega, BCL2 associated X protein transcript variant delta2, Bcl2-L-4, BCL2L4, membrane isoform alpha
Immunogen: Recombinant protein of human BAX
Swissprot: Q07812
Gene Accession: BC014175
Calculated MW: 21 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-20287/sc-20288/sc-6236/sc-526/sc-493
Citation(s):
https://link.springer.com/article/10.1007/s12011-018-1535-3
https://pubmed.ncbi.nlm.nih.gov/31830480/
https://pubmed.ncbi.nlm.nih.gov/32069824/
https://pubmed.ncbi.nlm.nih.gov/32476554/
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Research Area: Cancer, Cell Biology, Metabolism
Synonyms:
Apoptosis regulator BAX, BAX, Bax-protein, BAX, BAXA, Baxdelta2G9, Baxdelta2G9omega, Baxdelta2omega, Bcl-2-like protein 4, BCL2 associated X protein, BCL2 associated X protein omega, BCL2 associated X protein transcript variant delta2, Bcl2-L-4, BCL2L4, membrane isoform alpha
Immunogen: Recombinant protein of human BAX
Swissprot: Q07812
Gene Accession: BC014175
Calculated MW: 21 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-20287/sc-20288/sc-6236/sc-526/sc-493
Citation(s):
https://link.springer.com/article/10.1007/s12011-018-1535-3
https://pubmed.ncbi.nlm.nih.gov/31830480/
https://pubmed.ncbi.nlm.nih.gov/32069824/
https://pubmed.ncbi.nlm.nih.gov/32476554/
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