BBS10 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP4880b
Catalog Number: AC-AP4880b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB24715
Applications: FC, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB24715
Applications: FC, WB
Datasheet
Request Information
Background:
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
Other Names:
Bardet-Biedl syndrome 10 protein, BBS10, C12orf58
Target/Specificity:
This BBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-544 amino acids from the C-terminal region of human BBS10.
Antigen Region:
515-544
Antigen Type: Synthetic Peptide
Gene Name: BBS10
Gene ID: 79738
Primary Accession: Q8TAM1
NCBI Accession: NP_078961.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
Other Names:
Bardet-Biedl syndrome 10 protein, BBS10, C12orf58
Target/Specificity:
This BBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-544 amino acids from the C-terminal region of human BBS10.
Antigen Region:
515-544
Antigen Type: Synthetic Peptide
Gene Name: BBS10
Gene ID: 79738
Primary Accession: Q8TAM1
NCBI Accession: NP_078961.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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