Bcl-2 (clone 6B5), anti-human, mouse, rat

Background:
BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.

Synonyms: Apoptosis regulator Bcl 2, Bcl 2, B cell leukemia/lymphoma 2

Cellular Location: Mitochondrion outer membrane Nucleus membrane Endoplasmic reticulum membrane

Immunogen:
A synthetic peptide coupled to KLH

Gene Symbol: Bcl-2

Gene ID: 596

Swiss prot: P10415

Calculated MW: 26kDa

Recommended dilution:
WB 1:1000-2000, IF 1:100-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.