Bcl-2 Mouse mAb

Background:
BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.

Cellular localization: Mitochondrion outer membrane,Nucleus membrane,Endoplasmic reticulum membrane

Specificity: Human

Alternative Names:
B-Cell Leukemia/Lymphoma 2 ;B-Cell CLL/Lymphoma 2

Immunogen: Synthetic Peptide

Isotype: Mouse Monoclonal IgG1

Concentration: 1mg/ml

Recommended dilutions: WB 1:1,000-2,000, IHC 1:200, IF 1:100-200

Observed band: 26kDa

GeneID: 596

Swiss-Prot No.: P10415

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

NOTE: For Research Use Only