Bcl-2 Polyclonal Antibody

Background:
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms:
Bcl-2, PPP1R50, BCL2

Immunogen: A synthetic peptide of human Bcl-2

Swissprot: P10415
Gene ID: 596

Calculated MW: 22 kDa/26 kDa
Observed MW: 24 kDa/26 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.sciencedirect.com/science/article/pii/S0300483X18303937
https://link.springer.com/article/10.1007/s12011-018-1587-4
https://pubmed.ncbi.nlm.nih.gov/31830975/
https://pubmed.ncbi.nlm.nih.gov/31767147/