Bcl-6 polyclonal, anti-human, mouse

Background:
Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin's B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.

Alternative Name:
BCL-6, BCL-5, BCL6, BCL5, LAZ3, ZBTB27, ZNF51, B Cell Lymphoma 6 Protein, B-cell CLL/lymphoma 6, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein transcript, BCL5, BCL6A, cys-his2 zinc finger transcription factor, LAZ3, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc Finger Protein 51, zinc finger transcription factor BCL6S, ZNF51,

Application Dilution:
WB:1:1,000-1:5,000

Specificity: Bcl-6 polyclonal antibody detects endogenous levels of Bcl-6 protein.

Immunogen:
Recombinant protein

MW: 79 kDa

Swiss-Prot: P41182(Human) P41183(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.