Bcl-xL polyclonal, anti-human, mouse, rat antibody
€315.00
In stock
SKU
AC-ABV10236-100
Catalog Number: AC-ABV10236-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IP
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IP
Datasheet
Request Information
Background:
Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis thro µgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
Other Names:
Bcl-xL, Bcl-xS, BCL2L1, BCL2-like 1 protein
Primary Accession: Q92934
Gene Name: BAD
Gene ID: 572
Concentration (mg/ml): 0.5 mg/ml
Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis thro µgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
Other Names:
Bcl-xL, Bcl-xS, BCL2L1, BCL2-like 1 protein
Primary Accession: Q92934
Gene Name: BAD
Gene ID: 572
Concentration (mg/ml): 0.5 mg/ml
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