Bcl10 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue(MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain(CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are though to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are though to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Description:
Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10 (BCL10) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
AI132454 antibody, B cell CLL/lymphoma 10 antibody, B cell lymphoma/leukemia10 antibody, B-cell CLL/lymphoma 10 antibody, B-cell leukemia/lymphoma 10 antibody, B-cell lymphoma/leukemia 10 antibody, Bcl 10 antibody, Bcl-10 antibody, Bcl10 antibody, BCL10_HUMAN antibody, c E10 antibody, c-E10 antibody, C81403 antibody, CARD containing apoptotic signaling protein antibody, CARD containing molecule enhancing NF kappa B antibody, CARD containing molecule enhancing NF kB antibody, CARD containing molecule enhancing NF-kB antibody, CARD containing molecule enhancing NFkB antibody, CARD containing proapoptotic protein antibody, CARD like apoptotic protein antibody, CARD-containing apoptotic signaling protein antibody, CARD-containing molecule enhancing NF-kappa-B antibody, CARD-containing proapoptotic protein antibody, CARD-like apoptotic protein antibody, CARMEN antibody, Caspase recruiting domain containing protein antibody, caspase-recruiting domain-containing protein antibody, cCARMEN antibody, cE 10 antibody, cE10 antibody, CED 3/ICH 1 prodomain homologous E10 like regulator antibody, CED-3/ICH-1 prodomain homologous E10-like regulator antibody, CED3/ICH1 prodomain homologous E10 like regulator antibody, Cellular E10 antibody, Cellular homolog of vCARMEN antibody, Cellular-E10 antibody, CIPER antibody, CLAP antibody, hCLAP antibody, Mammalian CARD containing adapter molecule E10 antibody, Mammalian CARD-containing adapter molecule E10 antibody, mE 10 antibody, mE10 antibody, R-RCD1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl10(35-51aa ERHFDHLRAKKILSRED), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl10(35-51aa ERHFDHLRAKKILSRED), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.