BCL2A1 polyclonal, anti-human, mouse, rat

Background:
The Bcl-2 family of proteins is characterized by its ability to modulate cell death under a broad range of physiological conditions. Bcl-2 and Bcl-xL function to inhibit apoptosis while other members of the Bcl-2 family, Bax, Bad, Bak and Bcl-xS, oppose death-suppressing effects. An additional member of the family, A1 (also designated Bfl-1), dimerizes with both Bcl-2 and Bax and has been identified as a hematopoietic- specific, early inducible gene. While A1 demonstrates life promoting properties similar to those of Bcl-2, its function may be more temporally regulated during myeloid differentiation and dependent on additional growth stimuli to confer its life promoting properties. A1 is abundantly expressed in bone marrow and at low levels in other tissues. There is evidence that a correlation exists between a high expression of the A1 gene product and stomach cancer.

Alternative Name:
Bcl2-L-5, BCL2A1, ACC 1, ACC 2, B2LA1, Bcl 2 related protein A1, Bcl-2-like protein 5, Bcl-2-related protein A1, BCL2 related protein A1, Bcl2-L-5, BCL2A1, BCL2L5, BFL1, GRS, HBPA1, Hematopoietic BCL2 related protein A1, Hemopoietic specific early response protein, Hemopoietic-specific early response protein, Protein BFL 1, Protein BFL-1, Protein GRS,

Application Dilution:
WB:1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: BCL2A1 polyclonal antibody detects endogenous levels of BCL2A1 protein.

Immunogen:
recombinant protein

MW: 20 kDa

Swiss-Prot: Q16548(Human) Q07440(Mouse) Unigene:19770(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.