BCL2L1 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Synonyms: BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52

Cellular Location: Cytoplasm Cytoplasmic side Cytoplasmic vesicle Mitochondrion inner membrane Mitochondrion matrix Mitochondrion outer membrane Nucleus membrane Single-pass membrane protein centrosome cytoskeleton cytosol microtubule organizing center secretory vesicle synaptic vesicle membrane

Immunogen:
Recombinant protein of human BCL2L1

Gene Symbol: BCL2L1

Gene ID: 598

Swiss prot: Q07817

Calculated MW: 26kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-200, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.