BCL2L2 Polyclonal Antibody

Background:
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

Research Area: Cancer, Cell Biology

Synonyms:
Apoptosis regulator BCL W, Apoptosis regulator Bcl-W, B2CL2, BCL 2 Like 2, Bcl 2 like 2 protein, Bcl 2L2, BCL W, Bcl-2-like protein 2, Bcl2 L2, BCL2 like 2, BCL2 like 2 protein, Bcl2-L-2, Bcl2l2, BCLW, KIAA0271, PPP1R51, Protein phosphatase 1 regulatory subunit 51

Immunogen: Synthetic peptide of human BCL2L2

Swissprot: Q92843
Gene Accession: NP004041

Calculated MW: 21 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.8 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.