BCR Polyclonal Antibody

Background:
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Signal Transduction, Cancer

Synonyms:
ALL, bcr, BCR1, Breakpoint cluster region, CML, D22S11, D22S662, PHL, Renal carcinoma antigen NY-REN-26

Immunogen: Recombinant Human Breakpoint cluster region protein

Swissprot: P11274
Gene ID: 613

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.