BDNF polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Signaling Molecules and Interaction, Neurodegenerative Disorders, Nervous and Sensory Systems

Description:
Brain-derived neurotrophic factor (BDNF) during development promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. BDNF participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. BDNF is a major regulator of synaptic transmission and plasticity of adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Alternate Names: Brain-derived neurotrophic factor, BDNF, Abrineurin

Application Notes: E: 1:1,000-1:5,000; WB: 1:200-1:500

Accession No.: P23560

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BDNF.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.