Beclin-1 polyclonal, anti-human, mouse, rat
€365.00
In stock
SKU
200212
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Cancers, Cell Growth and Death, Folding, Sorting and Degradation, Infectious Diseases, Signaling Molecules and Interaction
Description:
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death. ULK1 protein kinase and the VPS34 lipid kinase are key regulators of autophagy initiation and progression. Activated during low nutrient conditions, ULK1 directly phosphorylates Beclin-1 at multiple sites including Ser15.
Alternate Names: Beclin-1 , Coiled-coil myosin-like Bcl-2-interacting protein, Protein GT197, BECN1
Application Notes: Cat. No. 200212 recognizes total Beclin-1, i.e. unphosphorylated and phosphorylated at Ser15 (Ser14 in mouse). E: 1:1,000-1:5,000; WB: 1:500-1:2,000
Accession No.: Q14457
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser15 of human beclin-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed 1 year from the date of shipment.
Pathway and Disease: Cancers, Cell Growth and Death, Folding, Sorting and Degradation, Infectious Diseases, Signaling Molecules and Interaction
Description:
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death. ULK1 protein kinase and the VPS34 lipid kinase are key regulators of autophagy initiation and progression. Activated during low nutrient conditions, ULK1 directly phosphorylates Beclin-1 at multiple sites including Ser15.
Alternate Names: Beclin-1 , Coiled-coil myosin-like Bcl-2-interacting protein, Protein GT197, BECN1
Application Notes: Cat. No. 200212 recognizes total Beclin-1, i.e. unphosphorylated and phosphorylated at Ser15 (Ser14 in mouse). E: 1:1,000-1:5,000; WB: 1:500-1:2,000
Accession No.: Q14457
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser15 of human beclin-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed 1 year from the date of shipment.
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