BECN1 polyclonal, anti-human, mouse, rat

Background:
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Synonyms: ATG6, VPS30, beclin1, APG6, ATG 6, GT197, VPS 30

Cellular Location: Cytoplasm Cytoplasmic vesicle Endoplasmic reticulum membrane Endosome Endosome membrane Golgi apparatus Mitochondrion Mitochondrion membrane Nucleus Peripheral membrane protein autophagosome trans-Golgi network membrane

Immunogen:
A synthetic peptide of human BECN1

Gene Symbol: BECN1

Gene ID: 8678

Swiss prot: Q14457

Calculated MW: 52kDa

Recommended dilution:
WB 1:2000-5000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.