Beta-2 Microglobulin (Renal Failure & Tumor Marker) (clone B2M/1118 ), anti-human

Background:
beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum β2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. β2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Other Names:
Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M

Gene Name: B2M (HGNC:914)
Gene ID: 567
Primary Accession: P61769
Other Accession: 567, 534255