Beta-2 Microglobulin (Renal Failure & Tumor Marker) (clone B2M/961 ), anti-human

Background:
Recognizes a protein of 12kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Other Names:
Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M

Gene Name: B2M (HGNC:914)
Gene ID: 567
Primary Accession: P61769
Other Accession: 567, 534255