Beta Arrestin 1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. By fluorescence in situ hybridization, this gene is mapped to 11q13.4. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase(BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.

Description:
Rabbit IgG polyclonal antibody for Beta-arrestin-1 (ARRB1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ARB1 antibody, ARR1 antibody, ARRB1 antibody, ARRB1_HUMAN antibody, Arrestin 2 antibody, Arrestin beta 1 antibody, Arrestin beta-1 antibody, Beta-arrestin-1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human beta Arrestin 1(82-103aa ANVQSFPPAPEDKKPLTRLQER), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the N-terminus of human beta Arrestin 1(82-103aa ANVQSFPPAPEDKKPLTRLQER), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.