beta-Catenin (p120) polyclonal, anti-human, mouse
€0.00
In stock
SKU
AC-AH10420
Catalog Number: AC-AH10420
Size: 20 µg, 100 µg
Isotype: Rabbit
Clone Name:
Applications: WB, IHC-P, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Rabbit
Clone Name:
Applications: WB, IHC-P, IF, FC
Datasheet
Request Information
Background:
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Other Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Gene Name: CTNNB1 (HGNC:2514)
Gene ID: 1499
Primary Accession: P35222
Other Accession: 1499, 476018
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Other Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Gene Name: CTNNB1 (HGNC:2514)
Gene ID: 1499
Primary Accession: P35222
Other Accession: 1499, 476018
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