BGLAP Polyclonal Antibody

Background:
Bone gamma-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner.

Research Area: Cancer, Signal Transduction, Stem Cells

Synonyms:
BGLAP, BGP, Bone gamma carboxyglutamate (gla) protein, Bone gamma carboxyglutamate gla protein osteocalcin, Bone gamma carboxyglutamate protein, Bone Gla protein, Gamma carboxyglutamic acid containing protein, Gamma-carboxyglutamic acid-containing protein, OC, OCN, OSTCN, Osteocalcin, OTTHUMP00000016586, PMF1

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Osteocalcin

Swissprot: P86546,P04640

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.84 mg/mL
Dilution: IHC 1:100-1:500

Storage:
Store at -20°C. Avoid freeze / thaw cycles.