BHMT (clone ), anti-human, mouse, rat
€428.00
In stock
SKU
MB9090
Background:
Betaine-homocysteine methyltransferase (BHMT) is a zinc-dependent cytosolic protein that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. BHMT is highly expressed in rat liver, and its expression is regulated by dietary methionine and choline. In humans, S-adenosylmethionine (SAM) down-regulates BHMT expression by inducing NFκB, which acts as a repressor for the BHMT gene. Lowered BHMT levels can lead to ER (endoplasmic reticulum) stress. Mutations in the gene encoding for BHMT may lead to hyperhomocysteinemia, a medical condition characterized by abnormally large amounts of homocysteine in the blood which may be a risk factor for cardiovascular and cerebrovascular diseases.
Alternative Name:
BHMT, Betaine homocysteine methyltransferase, Betaine homocysteine S methyltransferase 1, Betaine homocysteine S methyltransferase, Betainehomocysteine S-methyltransferase 1, BHMT, BHMT1, BHMT1, EC 2.1.1.5, Epididymis secretory sperm binding protein Li 61p, HEL S 61p,
Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50
IHC:1:50-1:200
FC:1:50-1:100
Specificity: BHMT monoclonal antibody detects endogenous levels of BHMT protein.
Immunogen:
Recombinant protein.
MW: 45 kDa
Swiss-Prot: Q93088(Human) 329582(Mouse) O09171(Rat)
Purification & Purity:
ProG affinity purified.
Format:
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
For research use only, not for use in diagnostic procedure.
Betaine-homocysteine methyltransferase (BHMT) is a zinc-dependent cytosolic protein that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. BHMT is highly expressed in rat liver, and its expression is regulated by dietary methionine and choline. In humans, S-adenosylmethionine (SAM) down-regulates BHMT expression by inducing NFκB, which acts as a repressor for the BHMT gene. Lowered BHMT levels can lead to ER (endoplasmic reticulum) stress. Mutations in the gene encoding for BHMT may lead to hyperhomocysteinemia, a medical condition characterized by abnormally large amounts of homocysteine in the blood which may be a risk factor for cardiovascular and cerebrovascular diseases.
Alternative Name:
BHMT, Betaine homocysteine methyltransferase, Betaine homocysteine S methyltransferase 1, Betaine homocysteine S methyltransferase, Betainehomocysteine S-methyltransferase 1, BHMT, BHMT1, BHMT1, EC 2.1.1.5, Epididymis secretory sperm binding protein Li 61p, HEL S 61p,
Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50
IHC:1:50-1:200
FC:1:50-1:100
Specificity: BHMT monoclonal antibody detects endogenous levels of BHMT protein.
Immunogen:
Recombinant protein.
MW: 45 kDa
Swiss-Prot: Q93088(Human) 329582(Mouse) O09171(Rat)
Purification & Purity:
ProG affinity purified.
Format:
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
For research use only, not for use in diagnostic procedure.
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