Bi-Phospho-JNK1(T183/Y185) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3752a
Background:
The protein encoded by this gene is a member of the MAPkinase family. MAP kinases act as an integration point for multiplebiochemical signals, and are involved in a wide variety of cellularprocesses such as proliferation, differentiation, transcriptionregulation and development. This kinase is activated by variouscell stimuli, and targets specific transcription factors, and thusmediates immediate-early gene expression in response to cellstimuli. The activation of this kinase by tumor-necrosis factoralpha (TNF-alpha) is found to be required for TNF-alpha inducedapoptosis. This kinase is also involved in UV radiation inducedapoptosis, which is thought to be related to cytochrom c-mediatedcell death pathway. Studies of the mouse counterpart of this genesuggested that this kinase play a key role in T cell proliferation,apoptosis and differentiation. Four alternatively splicedtranscript variants encoding distinct isoforms have been reported.
Other Names:
Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
Gene Name: MAPK8
Gene ID: 5599
Primary Accession: P45983
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of the MAPkinase family. MAP kinases act as an integration point for multiplebiochemical signals, and are involved in a wide variety of cellularprocesses such as proliferation, differentiation, transcriptionregulation and development. This kinase is activated by variouscell stimuli, and targets specific transcription factors, and thusmediates immediate-early gene expression in response to cellstimuli. The activation of this kinase by tumor-necrosis factoralpha (TNF-alpha) is found to be required for TNF-alpha inducedapoptosis. This kinase is also involved in UV radiation inducedapoptosis, which is thought to be related to cytochrom c-mediatedcell death pathway. Studies of the mouse counterpart of this genesuggested that this kinase play a key role in T cell proliferation,apoptosis and differentiation. Four alternatively splicedtranscript variants encoding distinct isoforms have been reported.
Other Names:
Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
Gene Name: MAPK8
Gene ID: 5599
Primary Accession: P45983
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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