Bi-Phospho-Syk(Y525/526) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3271a
Background:
Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.
Other Names:
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3271a was selected from the region of human Phospho-Syk-Y525/526. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SYK
Gene ID: 6850
Primary Accession: P43405
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.
Other Names:
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3271a was selected from the region of human Phospho-Syk-Y525/526. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SYK
Gene ID: 6850
Primary Accession: P43405
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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