Bi-Phospho-Syk(Y525/526) polyclonal, anti-human
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In stock
SKU
AC-AP3271a
Catalog Number: AC-AP3271a
Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB5669
Applications: WB, IHC-P
Datasheet
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Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB5669
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.
Other Names:
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
Target/Specificity:
This Syk Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y525/526 of human Syk.
Antigen Type: Synthetic Peptide
Gene Name: SYK
Gene ID: 6850
Primary Accession: P43405
NCBI Accession: NP_001128524.1;NP_001167638.1;NP_001167639.1;NP_003168.2
Other Accession: Q64725; Q00655; P48025
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.
Other Names:
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
Target/Specificity:
This Syk Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y525/526 of human Syk.
Antigen Type: Synthetic Peptide
Gene Name: SYK
Gene ID: 6850
Primary Accession: P43405
NCBI Accession: NP_001128524.1;NP_001167638.1;NP_001167639.1;NP_003168.2
Other Accession: Q64725; Q00655; P48025
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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