BID (phospho-Ser78) polyclonal, anti-human, mouse antibody
€355.00
In stock
SKU
AC-ABV11846-100
Catalog Number: AC-ABV11846-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Background:
Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
Other Names:
BH3-interacting domain death agonist, p22 BID, BID
Primary Accession: P55957
Gene Name: BID
Gene ID: 637
Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
Other Names:
BH3-interacting domain death agonist, p22 BID, BID
Primary Accession: P55957
Gene Name: BID
Gene ID: 637
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