Bim BH3 Domain polyclonal, anti-human
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In stock
SKU
AC-AP1308a
Catalog Number: AC-AP1308a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB00963
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB00963
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Other Names:
Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM
Target/Specificity:
This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 amino acids from human Bim BH3 Domain.
Antigen Region:
130-165
Antigen Type: Synthetic Peptide
Gene Name: BCL2L11
Gene ID: 10018
Primary Accession: O43521
NCBI Accession: NP_001191035.1;NP_001191036.1;NP_001191037.1;NP_001191038.1;NP_001191039.1;NP_001191040.1;NP_001191041.1;NP_001191042.1;NP_006529.1;NP_619527.1;NP_619528.1;NP_619529.1;NP_619530.1;NP_619531.1;NP_61953
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Other Names:
Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM
Target/Specificity:
This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 amino acids from human Bim BH3 Domain.
Antigen Region:
130-165
Antigen Type: Synthetic Peptide
Gene Name: BCL2L11
Gene ID: 10018
Primary Accession: O43521
NCBI Accession: NP_001191035.1;NP_001191036.1;NP_001191037.1;NP_001191038.1;NP_001191039.1;NP_001191040.1;NP_001191041.1;NP_001191042.1;NP_006529.1;NP_619527.1;NP_619528.1;NP_619529.1;NP_619530.1;NP_619531.1;NP_61953
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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