BIN1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Synonyms: AMPH2, AMPHL, SH3P9

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human BIN1

Gene Symbol: BIN1

Gene ID: 274

Swiss prot: O00499

Calculated MW: 65kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:20-50,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.