BIN1 Polyclonal Antibody

Background:
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Microbiology

Synonyms:
BIN1, AMPH2, AMPHL, SH3P9

Immunogen: Recombinant fusion protein of human BIN1 (NP_647601.1).

Swissprot: O00499
Gene ID: 274

Calculated MW: 45-64 kDa
Observed MW: 65 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.